(Fort Worth Fertility)

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Preimplantation Genetic Diagnosis (PGD)

In some cases, couples that are carriers of genetic disorders are reluctant to become pregnant because they are at risk of passing the disorder to their children. Preimplantation genetic diagnosis (PGD) is a procedure that can identify some genetic defects within an embryo before it is transferred into the uterus. It is also used in situations of repetitive miscarriages and to avoid aneuploidy (chromosomal problems such as downs syndrome).

The preimplantation genetic diagnosis procedure begins with the normal IVF process. Once the embryo is divided, preimplantation genetic diagnosis is performed at our IVF center.

Preimplantation genetic diagnosis involves the following steps:

  • A single cell is removed from the embryo
  • The cell is treated with probes for abnormalities
  • The DNA is evaluated to determine if the inheritance of the gene is present

Once the preimplantation genetic diagnosis procedure is complete and embryos without the genetic problems being tested have been identified, “normal” embryos are transferred into the uterus.

There are several benefits of preimplantation genetic diagnosis. It reduces the need for amniocentesis later in pregnancy. Preimplantation genetic diagnosis is performed before embryo implantation, so if a defect is identified, the couple can decide whether or not they want to continue with the pregnancy. But perhaps best of all, preimplantation genetic diagnosis enables couples that carry genetic disorders to try for a biological child of their own.

Preimplantation genetic diagnosis minimizes the risk of passing genetic defects on to future generations. If you or your partner has a genetic condition that you are afraid of transmitting to your child, preimplantation genetic diagnosis may be a good option for you.

After the embryo biopsy the single cells are sent for analysis.  These results are obtained in less than 48 hours and in 24 hours in some cases. The following are a list of the laboratories we utilize for evaluation.

Genesis Genetics Institute, LLC
5555 Conner Avenue, Suite 1100
Detroit, MI 48213
Tel/fax 313-544-4006
www.genesisgenetics.org

Reprogenetics
Tel (973) 436-5012
www.reprogenetics.com

Reproductive Genetics Institute
2825 North Halsted,
Chicago, Illinois 60657
Tel 773-472-4900
www.reproductivegenetics.com

Preimplantation genetic diagnosis minimizes the risk of passing genetic diseases to future generations and may help avoid miscarriages. If you or your partner have a genetic condition that you are afraid of passing on to your child or you are at risk for repetative miscarriages, preimplantation genetic diagnosis may be a good option for you.